AIb2.io - AI Research Decoded

March 24, 2026

A Cognitive Layer Architecture to Support LLM Performance in Psychotherapy

A Cognitive Layer Architecture to Support LLM Performance in Psychotherapy

Last month, a team of researchers published a paper in Nature Medicine claiming their AI system outperformed human therapists at cognitive behavioral therapy. And before you roll your eyes so hard they detach from your optic nerves, there's actually something genuinely interesting buried in here...

March 24, 2026

A Context-Augmented Large Language Model for Accurate Precision Oncology Medicine Recommendations

A Context-Augmented Large Language Model for Accurate Precision Oncology Medicine Recommendations

Last year, the FDA approved eight new cancer drugs in the first half alone - and that was a slow six months. For oncologists trying to match the right targeted therapy to the right genetic mutation in the right patient, the knowledge landscape isn't just expanding. It's detonating.

March 24, 2026

AI Is Predicting Drug Interactions From Molecular Structure, and Pharmacists Are Paying Attention

AI Is Predicting Drug Interactions From Molecular Structure, and Pharmacists Are Paying Attention

The average American over 65 takes four or more prescription medications. Each new drug added to the mix introduces a combinatorial explosion of potential interactions. Two drugs? One possible interaction. Five drugs? Ten possible pairs. Ten drugs? Forty-five pairs to check. Twenty drugs? 190...

March 24, 2026

AlphaFold Just Learned That Proteins Have Friends

AlphaFold Just Learned That Proteins Have Friends

Proteins don't work alone. They buddy up, form cliques, and get into complicated relationships that make your high school social dynamics look straightforward. And until last week, the most important protein structure database on the planet had been pretending otherwise.

March 24, 2026

Beijing Just Dropped a Five-Year Plan, and AI Got Top Billing

Beijing Just Dropped a Five-Year Plan, and AI Got Top Billing

Somewhere in a Beijing conference room, someone circled "artificial intelligence" on a whiteboard so many times the marker ran dry. China's 15th Five-Year Plan (2026-2030) just landed, and it reads less like a policy document and more like a love letter to AI - complete with a $62 billion science...

March 24, 2026

GPT-5 Made Better Surgery Checklists Than Humans, and That Should Make You Think

GPT-5 Made Better Surgery Checklists Than Humans, and That Should Make You Think

Surgeons live and die by checklists. Not metaphorically - literally. The Enhanced Recovery After Surgery (ERAS) protocol is basically a to-do list that says things like "give the patient this drug at this time" and "get them walking by day two." When hospitals actually follow these checklists,...

March 24, 2026

Integrated Photonic Neural Network with On-Chip Backpropagation Training

Integrated Photonic Neural Network with On-Chip Backpropagation Training

A chip that trains itself using light instead of electricity just landed in Nature, and it might be the most important thing to happen to AI hardware since someone decided to strap thousands of GPUs together and pray the cooling system held up.

March 24, 2026

Manufacturing-Aware Generative Models Enable Petascale Synthesis of Designed DNA

Manufacturing-Aware Generative Models Enable Petascale Synthesis of Designed DNA

A hundred quadrillion dollars. That's roughly $10^15 - about a thousand times the entire US GDP. It's also what it would cost to individually synthesize the DNA library that a team from JURA Bio and Harvard just produced for around a thousand bucks.

March 24, 2026

RAG: Teaching AI to Look Stuff Up Instead of Just Guessing

RAG: Teaching AI to Look Stuff Up Instead of Just Guessing

There's a fundamental absurdity in how large language models work. You train them on hundreds of billions of words, freeze their knowledge at a cutoff date, and then ask them questions about the world as if they're an encyclopedia that stopped updating in 2024. "What's the latest treatment...

March 24, 2026

RLHF: The Training Technique That Turned ChatGPT From Unhinged to Useful

RLHF: The Training Technique That Turned ChatGPT From Unhinged to Useful

Before RLHF, large language models were like that friend who's read everything but has absolutely no social awareness. They could generate fluent text, sure, but they'd also cheerfully write you instructions for making explosives, follow it with a racist limerick, and then confidently explain that...